江中兴

职务/职称：教授、博士生导师

通讯地址：bat365在线唯一官网登录（湖北省武汉市东湖路185号）

课题组地址：武汉大学医学部一号楼六楼

电子邮箱：zxjiang@whu.edu.cn

课题组网页链接  https://jiangzhongxing.icoc.cc/

学习与工作简历

1995年9月至1999年7月         西南师范大学化学化工学院获理学学士学位

1999年8月至2004年7月         中科院上海有机化学研究所获化学博士学位

2004年8月至2007年4月         美国犹他大学bat365在线唯一官网登录博士后研究员

2007年4月至2008年8月         美国印第安纳大学医学院博士后研究员

2008年8月至2011年10月        美国马里兰大学bat365在线唯一官网登录研究助理教授

2011年10月至今               bat365在线唯一官网登录教授、博士生导师

研究方向

单一分子量聚乙二醇修饰的多肽/蛋白药物

药物的氟-19可视化传输与缓释

含氟药物的合成与其在化学生物学中的应用

业绩概要

在SCI期刊上发表文章60余篇，文章被引用1000余次，H-index>18；申请专利10余项，授权专利6项；受邀为Theranostics, Chemical Science, Bioconjugate. Chemistry, Chemical Communications, Journal of Organic Chemistry, Molecular Pharmaceutics等10余个SCI期刊审稿人；主持国家自然科学基金面上项目和国家重大研发计划子课题等10余个研究项目；指导多个国家级大学生创新创业项目；担任湖北省药学会委员。

获得荣誉

2015年 武汉大学医学部突出贡献奖

2016年 武汉大学朱裕璧医学奖

主要科研项目

1.“慢阻肺药物个性化干预与治疗的新技术和新方法”，国家重点研发计划，子课题负责人，课题编号2016YFC1304704，2016年-2020年

2. “基于单一分子量聚乙二醇的生物材料的设计、合成及其在生物大分子药物研发中的应用”，国家自然科学基金面上项目，批准号21572168，2016年-2019年

3.“F-19 MRI 可视化5-FU 传输载体的合成与应用研究”， 国家自然科学基金面上项目，批准号21372181，2014年-2017年

最近发表文章

1. Zhang, H.; Li, Y.; Chen, S.; Yuan, Y.; Jiang, Z.-X.;* Zhou, X.* “129Xe hyper-CEST/19F MRI multimodal imaging system for sensitive tumor cells detection” ACS Appl. Bio Mater. 2019, 2, 27-32.

2. Zhu, J.; Xiao, Y.; Zhang, H.; Li, Y.; Yuan, Y.; Yang, Z.; Chen, S.; Zheng, X.; Zhou, X.; Jiang, Z.-X.* “Peptide monodisperse PEG “combs” with fine-tunable LCST and multiple imaging modalities” Biomacromolecules 2019, doi: 10.1021/acs.biomac.8b01693

3. Deng, T.; Mao, X.; Xiao, Y.; Yang, Z.; Zheng, X.; Jiang, Z.-X.* “Monodisperse oligoethylene glycols modified Camptothecin, 10-hydroxycamptothecin and SN38 prodrugs” Bioorg. Med. Chem. Lett. 2019, 29, 581-584.

4. Li, Y.; Wang, X.; Chen, Y.; Yang, Z.; Jiang, Z.-X.* “Monodisperse polyethylene glycols “brushes” with enhanced lipophilicity, thermos and plasma stability” Chem. Commun. 2019, 55, 1895-1898.

5. Taraban, M. B.; Deredge, D. J.; Smith, M. E.; Briggs, K. T.; Li, Y.; Jiang, Z.-X.; Wintrode, P. L.;* Yu, Y. B.* “Monitoring dendrimer conformational transition using 19F and 1H2O NMR” Magn. Reson. Chem. 2019, doi: 10.1002/mrc.4849.

6. Xue, D.; Wang, J.; Song, X.; Wang, W.; Ye, L.; Liu, Y.; Zhou, Q.; Jiang, Z.-X.; Liu Z.-J.; Tan, H.* “Chemical amphiphile replacement strategy for membrane protein research” Langmuir, 2019, doi: 10.1021/acs.langmuir.8b04072.

7. Taraban, M. B.; Deredge, D. J.; Smith, M. E.; Briggs, K. T.; Feng, Y.; Li, Y.; Jiang, Z.-X.; Wintrode, P. L.;* Yu, Y. B.* “Conformational transition of a non-associative fluorinated amphiphile in aqueous solution. II. Conformational transition vs. supramolecular assembly” RSC Adv. 2019, 9, 1956-1966.

8. Liu, X.; Jiang, Z.-X.; Yu, B. Y.; Jeong, E.-K.* “Study of kinetics of 19F-MRI using a fluorinated imaging agent (19FIT) on a 3T clinical MRI system” Magn. Reson. Mater. Phys. Biol. Med. 2018, doi: 10.1007/s10334-018-0707-7.

9. Lv, X.; Zheng, X.; Yang, Z.; Jiang, Z.-X.* “One-pot synthesis of monodisperse dual-functionalized polyethylene glycols through macrocyclic sulfates” Org. Biomol. Chem. 2018, 16, 8537-8545.

10. Jia, Y.; Chen, L.; Zhang, H.; Zheng, Y.; Jiang, Z.-X.; Yang, Z.* “Electrophilic chloro(ω-alkoxy) lation of alkene employing 1-chloro-1,2-benzoidoxol-3-one: facile synthesis of β-chloroethers” Org. Biomol. Chem. 2018, 16, 7203-7213.

11. Deng, T.; Mao, X.; Li, Y.; Bo, S.; Yang, Z.; Jiang, Z.-X.* “Monodisperse oligoethylene glycols modified Propofol prodrugs” Bioorg. Med. Chem. Lett. 2018, 28, 3502-3505.
    

    
    

12. Peng, Q.; Li, Y.; Bo, S.; Yuan, Y.; Yang, Z.; Chen, S.; Zhou, X.; Jiang, Z.-X.* “Paramagnetic nanoemulsions with unified signal for sensitive 19F MRI cell tracking” Chem. Commun. 2018, 54, 6000-6003.

13. Bo, S.; Yuan, Y.; Chen, Y.; Yang, Z.; Chen, S.; Zhou, X.; Jiang, Z.-X.* “In vivo drug tracking with 19F MRI at therapeutic dose” Chem. Commun. 2018, 54, 3875-3878.

14. Jia, Y.; Qin, H.; Wang, N.; Jiang, Z.-X.; Yang, Z.* “Fe2O3-promoted intermolecular chlorotrifluoro-methylthiolation of alkenes” J. Org. Chem. 2018, 83, 2808-2817.

15. Li, Y.; Shi, Q.; Shao, J.; Yuan, Y.; Yang, Z.; Chen, S.; Zhou, X.; Wen, S.; Jiang, Z.-X.* “Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives” Eur. J. Med. Chem. 2018, 148, 279-290.

16. Yu, Z.; Bo, S.; Wang, H.; Li, Y.; Yang, Z.; Huang, Y.; Jiang, Z.-X.* “Application of monodisperse PEGs in pharmaceutics: monodisperse polidocanols” Mol. Pharm. 2017, 14, 3473-3479.

17. Peng, Q.; Yuan, Y.; Zhang, H.; Bo, S.; Li, Y.; Chen, S.; Yang, Z.; Zhou, X.; Jiang, Z.-X.* “19F CEST imaging probes for metal ion detection” Org. Biomol. Chem. 2017, 15, 6441-6446.

18. Liu, X.; Yuan, Y.; Bo, S.; Li, Y.; Yang, Z.; Zhou, X.; Chen, S.*; Jiang, Z.-X.* “Monitoring fluorinated dendrimer-based self-assembled drug-delivery systems with 19F magnetic resonance” Eur. J. Org. Chem. 2017, 4461-4468.

19. Xing, H.; Chen, L.; Jia. Y.; Jiang, Z.-X.*; Yang, Z.* “Fe2O3-catalyzed Pummerer rearrangement of acyl chlorides and sulfoxides: facile synthesis of alkylthiomethyl ester” Tetrahedron Lett. 2017, 58, 2199-2202.

20. Wang, M.; Lei, D.; Liu, Z.; Chen, S.; Sun, L.; Lv, Z.; Huang, P.; Jiang, Z.-X.*; You, Z.* “A poly(glycerol sebacate) based photo/thermo dual curable biodegradable and biocompatible polymer for biomedical applications” J. Biomater. Sci., Polymer Ed. 2017, 28, 1728-1739.

21. Shi, Q.; Li, Y.; Bo, S.; Li, X.; Zhao, P.; Liu, Q.; Yang, Z.; Cong, H.; Deng, H.; Chen, M.; Chen, S.; Zhou, X.; Ding, H.; Jiang, Z.-X.* “Discovery of a 19F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells” Chem. Commun. 2016, 52, 5136-5139.

22. Zhao, P.; Xia, G.; Dong, S.; Jiang, Z.-X.; Chen, M.* “An iTEP-salinomycin nanoparticle that specifically and effectively inhibits metastases of 4T1 orthotopic breast tumors” Biomaterials 2016, 93, 1-9.

23. Li, Y.; Xia, G.; Guo, Q.; Wu, L.; Chen, S.; Yang, Z.; Wang, W.; Zhang, Z.-Y.; Zhou, X.; Jiang, Z.-X.* “Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors” MedChemComm 2016, 7, 1672-1680.

24. Wan, Z.; Yu, L.; Bo, S.; Gao, M.; Wang, X.; Zeng, K.; Tao, X.; Li, X.; Yang, Z.*; Jiang, Z.-X.* “Amide bond-containing monodisperse poly(ethylene glycol)s beyond 10000 Da” Org. Biomol. Chem. 2016, 14, 7912-7919 (Hot paper of the month and the year).

25. Chen, L.; Xing, H.; Zhang, H.; Jiang, Z.-X.*; Yang, Z.* “Copper-catalyzed intermolecular chloroazidation of α, β-unsaturated amides” Org. Biomol. Chem. 2016, 14, 7463-7467.

26. Fu, M.; Chen, L.; Jiang, Y.; Jiang, Z.-X.*; Yang, Z.* “Copper-catalyzed intermolecular chloro- and bromotrifluoromethylation of alkenes” Org. Lett. 2016, 18, 348-351.

27. Li, X.; Feng, Z.; Jiang, Z.-X.*; Zhang, X.* “Mild nickel-catalyzed reductive cross-coupling of (hetero)aryl iodides with fluorinated secondary alkyl bromides” Org. Lett. 2015, 17, 5570-5573.

28. Xia, G.; Li, Y.; Yang, Z.; Jiang, Z.-X.* “Development of a scalable process for α-amino-ω-methoxyl-dodecaethylene glycol” Org. Process Res. Dev. 2015, 19, 1769-1773.

29. Li, Y.; Qiu, X.-L.; Jiang, Z.-X.* “Macrocyclic sulfates as versatile building blocks in the synthesis of monodisperse poly(ethylene glycol)s and monofunctionalized derivatives” Org. Process Res. Dev. 2015, 19, 800-805.

30. Bo, S.; Song, C.; Li, Y.; Yu, W.; Chen, S.; Zhou, X.; Yang, Z.; Zheng, X.*; Jiang, Z.-X.* “Design and synthesis of fluorinated amphiphile as 19F MRI/fluorescence dual-imaging agent by tuning the self-assembly” J. Org. Chem. 2015, 80, 6360-6366.

31. Yu, W.; Yang, Y.; Bo, S.; Li, Y.; Chen, S.; Yang, Z.; Zheng, X.; Jiang, Z.-X.*; Zhou, X. “Design and synthesis of fluorinated dendrimers for sensitive 19F MRI” J. Org. Chem. 2015, 80, 4443-4447.
    

    
    

32. Zhang, H.; Li, X.; Shi, Q.; Li, Y.; Xia, G.; Chen, L.; Yang, Z.; Jiang, Z.-X.* “Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)” Angew. Chem., Int. Ed. 2015, 54, 3763-3767.