辜美佳
职称/职务：副教授、组合生物合成与新药发现教育部重点实验室办公室主任
通讯地址：武汉大学医学部8号楼808室
学习工作简历：
2002–2006 学士 武汉大学，生命科学学院，生物技术
2006–2011 博士研究生（硕博连读） 武汉大学，生命科学学院，微生物学
2010–2011 访问博士研究生 美国俄亥俄州立大学，病理系
2011–2013 师资博士后 bat365在线唯一官网登录组合生物合成与新药发现教育部重点实验室
2014–2015 博士后 美国哈佛大学医学院Dana-Farber Cancer Institute
2014–2021 讲师 bat365在线唯一官网登录
2022至今 副教授 bat365在线唯一官网登录
业绩概要:
以一作或通讯作者在 Advanced Functional Materials, Advanced Science, Small, Cancer Letters, Journal of Medicinal Chemistry、International Journal of Cancer, Materials Chemistry Frontiers, Biotechnology Journal等期刊发表科研论文。
研究兴趣与方向:
1． 新型分子探针的生物医学应用
荧光生物探针在生物成像和荧光传感方面发挥着重要的作用，可以作为可视化工具研究复杂的生物结构和生命过程。我们主要发展基于聚集诱导发光、近红外二区等新型荧光小分子，致力于发展能够应用于肿瘤、细菌及病毒感染、组织缺血等重要疾病的诊断与治疗的新材料与新方法。
2． 噬菌体感染机制及应用
噬菌体是一种感染细菌和古细菌的病毒，其特点是以细菌为宿主，专门攻击特定的细菌，因此可以作为抗生素的替代品。随着抗生素的大量使用，一些细菌对抗生素产生了耐药性。与不耐药的细菌相比，这些细菌造成的感染更难治疗。我们致力于针对多重耐药性细菌导致的难治性感染，使用噬菌体治疗成为一种有前途的研究方向。
承担课题与经费：
（1）主持国家自然科学基金青年基金项目
（2）主持国家重点研发计划项目子课题
（3）主持科技部973计划子课题
（4）主持中国博士后科学基金面上资助项目
（5）主持武汉大学横向科研项目
（6）主持武汉大学自主科研项目
（7）主持武汉大学交叉学科类科研项目
（8）主持湖北省博士后科技活动项目择优资助
教学情况：
《微生物与免疫学》、《生物技术制药实验》
科研成果（*：通讯作者，#：第一作者）:
1. Meijia Gu, Susu Jiang, Xiaoyu Xu, Ming-Yu Wu, Chao Chen, Yuncong Yuan, Qingrong Chen, Yidan Sun, Luojia Chen, Chao Shen, Peng Guo, Shujie Liu, Engui Zhao*, Shi Chen*, Sijie Chen*. Simultaneous Photodynamic Eradication of Tooth Biofilm and Tooth Whitening with an Aggregation-Induced Emission Luminogen, Advanced Science, 2022 May 7:e2106071. DOI: 10.1002/advs.202106071.
2. Libei Huang#, Meijia Gu#, Zhaoyu Wang, Tsz Wing Tang, Zonglong Zhu, Yuncong Yuan, Dong Wang, Chao Shen*, Ben Zhong Tang*, Ruquan Ye*. Highly Efficient and Rapid Inactivation of Coronavirus on Non-Metal Hydrophobic Laser-Induced Graphene in Mild Conditions, Advanced Functional Materials, 2021 Jun 9;31(24):2101195. DOI: 10.1002/adfm.202101195.
3. Meijia Gu*#, Libei Huang#, Zhaoyu Wang, Weihua Guo, Le Cheng, Yuncong Yuan, Zhou Zhou, Liu Hu, Sijie Chen, Chao Shen*, Ben Zhong Tang*, Ruquan Ye*. Molecular Engineering of Laser-Induced Graphene for Potential-Driven Broad-Spectrum Antimicrobial and Antiviral Applications, Small, 2021 Dec;17(51):e2102841. DOI: 10.1002/smll.202102841.
4. Ming-Yu Wu#, Meijia Gu#, Jong-Kai Leung, Xinmei Li, Yuncong Yuan, Chao Shen, Lianrong Wang*, Engui Zhao*, Sijie Chen*. A Membrane-Targeting Photosensitizer with Aggregation-Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses, Small, 2021 July;17(30):e2101770. DOI: 10.1002/smll.202101770.
5. Yishen Liu#, Qianqian Li#, Meijia Gu#, Disheng Lu#, Xiaoxing Xiong#, Zhiyun Zhang Yanna Pan, Yuqin Liao, Qihang Ding, Wanxia Gong, Dean Shuailin Chen, Mengting Guan, Junzhu Wu, Zhiquan Tian, Hai Deng, Lijuan Gu, Xuechuan Hong*, Yuling Xiao*. A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy, Journal of Medicinal Chemistry, 2022 Feb 10;65(3):2225-2237. DOI: 10.1021/acs.jmedchem.1c01736.
6. Meijia Gu, Hua Li, Chao Shen, Lin Wu, Wanhong Liu, Lixia Miao, Congyi Zheng*, Cloning and characterization of a new BRCA1 variant: A role for BRCT domains in apoptosis, Cancer Letters, 2010 Sep 28;295(2):205-13. DOI: 10.1016/j.canlet.2010.03.002.
7. Meijia Gu#, Ming-Yu Wu#, Yuncong Yuan, Po-Yu Ho, Zhou Zhou, Engui Zhao*, Chao Shen* and Sijie Chen*. Isoquinolinium-based photosensitizers with aggregation-induced emission characteristics for highly efficient photodynamic combat of viruses, Materials Chemistry Frontiers, 2022 Aug. DOI: 10.1039/d2qm00630h.
8. Meijia Gu, Meimei Yang, Jing He, Sixuan Xia, Zhe Zhang, Yudong Wang, Congyi Zheng, Chao Shen*. A silver lining in cell line authentication: Short tandem repeat analysis of 1373 cases in China from 2010 to 2019, International Journal of Cancer, 2022 Feb 1;150(3):502-508. DOI: 10.1002/ijc.33789.
9. Meijia Gu, Zixuan Zeng, Mai Xing, Yige Xiong, Zixin Deng, Shi Chen, Lianrong Wang*. The Biological Applications of Two Aggregation-Induced Emission Luminogens, Biotechnology Journal, 2019 Dec;14(12):e1900212. DOI:10.1002/biot.201900212.
10. Meijia Gu, Zixuan Zeng, Ming-Yu Wu, Jong-Kai Leung, Engui Zhao*, Shidong Wang, Sijie Chen*, Imaging Macrophage Phagocytosis Using AIE Luminogen-Labeled E.coli, Chemistry—An Asian Journal, 2019 Mar 15;14(6):775-780. doi: 10.1002/asia.201801859.
11. Meijia Gu, Ti He, Yuncong Yuan, Suling Duan, Xin Li*, and Chao Shen*, Single-Cell RNA Sequencing Reveals Multiple Pathways and the Tumor Microenvironment Could Lead to Chemotherapy Resistance in Cervical Cancer, Frontiers in Oncology, 2021 Nov 26;11:753386. DOI: 10.3389/fonc.2021.753386.
12. Meijia Gu*#, Huaqin Pan#, Yuncong Yuan, Xuemin Zhou, Luojia Chen, Xingran Wang, Fang Fang, Liu Hu, Yaxuan Xie, Chao Shen*, Sera Metabolomics Characterization of Patients at Different Stages in Wuhan Identifies Critical Biomarkers of COVID-19, Frontiers in Cellular and Infection Microbiology, 2022 May 2;12:882661. DOI: 10.3389/fcimb.2022.882661. eCollection 2022.
13. Meijia Gu, Jingxuan Liu, Meimei Yang, Mingmin Zhang, Jian Yang, Suling Duan, Xuxu Ding, Jie Liu, Chuguang Chen, Yundian Zeng, Chao Shen*, Advantages of a 21-loci short tandem repeat method for detection of cross-contamination in human cell lines, Gene, 2020 Dec 30;763:145048. DOI: 10.1016/j.gene.2020.145048.
14. Meijia Gu, Chao Shen*, Novel cancer cell lines derived from primary breast tumors in Chinese patients, American Journal of Translational Research, 2018 Dec 15;10(12):3956-3968.
15. Zixuan Zeng, Xiaojiao Ren, Tailang Yin, Xiang Gao, Mengting Tsai, Yi Zhang, Meijia Gu*, Multiplexed detection and the establishment of a novel high-throughput method for human germ cell quality screening based on aggregation-induced emission, American Journal of Translational Research, 2019 Nov 15;11(11):6907-6923.
