赵昌明

性别：男

职务/职称: 教授

通讯地址（含邮编）：

湖北省武汉市武昌区东湖路185号bat365在线唯一官网登录，430071

办公地址：湖北省武汉市珞珈山武汉大学测试中心“组合生物合成与新药发现教育部重点实验室”C409

研究领域:

微生物来源的含磷天然产物的发掘与生物合成研究

研究兴趣与方向:

天然产物（Natural product）是现代药物开发的重要源泉，临床使用的化学药物近一半直接或间接来源于天然产物。以放线菌为代表的微生物更是重中之重，它们产生具有抗感染、肿瘤抑制、免疫抑制等不同活性的天然产物，被开发成药物广泛应用于临床治疗。本人的研究兴趣在于通过生物信息学、分子生物学、生物化学和有机化学的手段，从放线菌中发掘具有特定化学结构的天然产物（比如含有碳-磷键的化合物和含有氮-磷键的化合物），解析其生物合成途径、改造其分子结构，以开发物美（活性好）价廉（产量高）的天然产物新药。

学习经历：

2017.9---2019.12，波士顿大学，化学系，访问学者

2010.6---2011.12，伊利诺伊大学香槟校区（UIUC）基因组生物研究所，博士后

2008.6---2010.5，上海交通大学，生命科学学院，博士后

2001.9---2007.12，华中农业大学，生命科学技术学院，博士

1997.9---2001.7， 华中农业大学，生命科学技术学院，本科

工作经历：

2020.12---现在，bat365在线唯一官网登录，教授

2012.1---2020.11，bat365在线唯一官网登录，副教授

主讲课程:

基因工程，生物技术制药

发表的研究论文（代表作）：

1. Chen L, Deng Z, Zhao C*. Nitrogen-Nitrogen Bond Formation Reactions Involved in Natural Product Biosynthesis. ACS Chem Biol. 2021 Apr 16;16(4):559-570. doi: 10.1021/acschembio.1c00052.

2. Deng Q, Liu Y, Chen L, Xu M, Naowarojna N, Lee N, Chen L, Zhu D, Hong X, Deng Z, Liu P*, Zhao C*. Biochemical Characterization of a Multifunctional Mononuclear Nonheme Iron Enzyme (PtlD) in Neopentalenoketolactone Biosynthesis. Org Lett. 2019 Sep 20;21(18):7592-7596. doi: 10.1021/acs.orglett.9b02872.

3. Deng Q, Xiao L, Liu Y, Zhang L, Deng Z, Zhao C*. Streptomyces avermitilis industrial strain as cell factory for Ivermectin B1a production. Synth Syst Biotechnol. 2019 Ma;4(1):34-39. doi: 10.1016/j.synbio.2018.12.003

4. Chen L#, Naowarojna N#, Chen B, Xu M,  Quill M, Wang J,  Deng Z,  Zhao C*, and  Liu P*. Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr). ACS Catal. 2019, 9(1): 253-258. doi: 10.1021/acscatal.8b03903

5. Naowarojna N#, Cheng R#, Chen L#, Quill M, Xu M, Zhao C*, Liu P*. Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis. Biochemistry. 2018 Jun 19;57(24):3309-3325. doi: 10.1021/acs.biochem.8b00239.

6. Chen L, Naowarojna N, Song H, Wang S, Wang J, Deng Z, Zhao C*, Liu P*. Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C-S Bond Formation. J Am Chem Soc. 2018 Apr 4;140(13):4604-4612. doi: 10.1021/jacs.7b13628.

7. Deng Q, Zhou L, Luo M, Deng Z, Zhao C*. Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers. Synth Syst Biotechnol. 2017 Mar 24;2(1):59-64. doi: 10.1016/j.synbio.2017.03.001.

8. Li M, Chen L, Deng Z, Zhao C*. Characterization of AmtA, an amidinotransferase involved in the biosynthesis of phaseolotoxins. FEBS Open Bio. 2016 May 16;6(6):603-9. doi: 10.1002/2211-5463.12071.

9. Chen L, Li P, Deng Z, Zhao C*. Ornithine Transcarbamylase ArgK Plays a Dual role for the Self-defense of Phaseolotoxin Producing Pseudomonas syringae pv. phaseolicola. Sci Rep. 2015 Aug 10;5:12892. doi: 10.1038/srep12892.

10. Hao C#, Huang S#, Deng Z, Zhao C*, Yu Y*. Mining of the pyrrolamide antibiotics analogs in Streptomyces netropsis reveals the amidohydrolase-dependent "iterative strategy" underlying the pyrrole polymerization. PLoS One. 2014 Jun 5;9(6):e99077. doi: 10.1371/journal.pone.0099077.

11. Evans BS*, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW*. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. ACS Chem Biol. 2013 May 17;8(5):908-13. doi: 10.1021/cb400102t.

12. Zhao C, Huang T, Chen W, Deng Z*. Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster. Appl Environ Microbiol. 2010. 76(21):7343-7347

13. Zhao C, Song C, Yu Z and Sun M*. L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520. FEBS Lett. 2008. 582(20):3125-3131

14. Zhao C, Zeng H, Yu Z and Sun M*. N-acyl homoserine lactonase promotes prevention of Erwinia virulence with Zwittermicin A producing strain Bacillus cereus. Biotechnol Bioeng. 2008. 100(3):599-603

15. Zhao C, Luo Y, Song C, Liu Z, Chen S, Yu Z and Sun M*. Identification of three Zwittermicin A biosynthesis-related genes from Bacillus thuringiensis subsp. kurstaki strain YBT-1520. Arch Microbiol. 2007. 187(4):313-319

参编教材：

普通高等教育“十二五”国家级规划教材《基因工程》第二版，孙明主编，高等教育出版社，2013.（第十八章，医药基因工程）