鲁丽

职称/职务：特聘研究员

通讯地址：湖北省武汉市武昌区东湖路185号bat365在线唯一官网登录，430071

办公地址：武汉大学医学部1号楼

学习简历：

2003.09 - 2007.07 华中农业大学，生命科学与技术学院，生物科学理科基地,本科

2006.09 - 2012.12 华中农业大学，生命科学与技术学院，遗传学，博士

工作简历：

2014.04 - 2017.12 美国威斯康星大学麦迪逊分校，遗传学系，博士后

2017.12 - 2018.12 美国威斯康星大学麦迪逊分校，医学研究院，助理研究员

2019.09   至今  bat365在线唯一官网登录，特聘研究员

研究领域:

植物来源天然产物的分子合成途径、天然产物的生物合成、基因组学

研究兴趣与方向:

植物来源天然产物如青蒿素、吗啡、长春花碱等，在医药领域有着广泛的应用，也是中国传统中药发挥功能的有效成分。本课题组主要关注植物来源天然产物的生物合成，具体包括：1、结合基因组学、生物信息分析，研究我国珍稀药用植物的基因组和分子进化、挖掘植物次生代谢相关基因；2、利用生物化学和分子生物学手段，解析药用植物中有效成分的分子合成途径；3、将天然产物的分子合成途径转嫁到微生物、模式植物底盘，开发高效的生物合成平台。

代表性论文:

1.Li Lu, Fen Zhu, Yangguang Li, Shuichi Kimpara, Nguyet Minh Hoang, Sheida Pourdashti and Lixin Rui. Inhibition of the STAT3 target SGK1 sensitizes diffuse large B cell lymphoma cells to AKT inhibitors. Blood Cancer journal, 9 (43), 2019.

2.Li Lu#, Xiangsong Chen#, Shuiming Qian, Xuehua Zhong. The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution. Nature communications, 9 (1), 630, 2018.

3.Li Lu#, Fen Zhu#, Meili Zhang#, Yangguang Li, Amanda C. Drennan, Shuichi Kimpara & Lixin Rui. Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma. PNAS, 115 (3), E498-E505, 2018.

4.Hao Zeng#, Li Lu#, Xuehua Zhong & Wei Xu. Systematic identification of Ctr9 regulome in ERα-positive breast cancer. BMC genomics, 17(1), 902, 2016.

5.Li Lu, Xiangsong Chen, Dean Sanders, Shuiming Qian, Xuehua Zhong. High-resolution mapping of H4K16 and H3K23 acetylation reveals conserved and unique distribution patterns in Arabidopsis and rice. Epigenetics, 10 (11), 1044-1053, 2015.

6.Yang Lei#, Li Lu#, Hai-Yang Liu, Sen Li, Feng Xing, Ling-Ling Chen. CRISPR-P: A web tool for synthetic single-guide RNA design of CRISPR-system in plants. Molecular Plant, 9:1494-1496, 2014.

7.Li Lu, Di Shao, Xianjing Qiu, Liang Sun, Xiangchun Zhou, Wenhao Yan, Lin Yang, Yuqing He, Sibin Yu, Yongzhong Xing. Natural variation and artificial selection in four genes determine grain shape in rice. New Phytologist, 200:1269-1280, 2013.

8.Li Lu#, Wenhao Yan#, Weiya Xue, Di Shao, Yongzhong Xing. Evolution and association analysis of Ghd7 in rice. PLoS ONE, 7: e34021, 2012.

9.Hui Li#, Li Lu#, Yanfang Heng, Rui Qin, Yongzhong Xing, Weiwei Jin. Expression of CENH3 alleles in synthesized allopolyploid Oryza species. Journal of Genetics and Genomics, 37:703-711, 2010.

10.Fen Zhu, Hui Guo, Paul D. Bates, Shanxiang Zhang, Hui Zhang, Krystle J. Nomie, Yangguang Li, Li Lu, & Lixin Rui. PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K/AKT in lymphoma cells. Leukemia, 33, 2898–2911, 2019.

11.Zhenlin Yang, Shuiming Qian, Ray Scheid, Li Lu & Xuehua Zhong. EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nature Genetics 50(9),1247, 2018.

12.Shuiming Qian, Xinchen Lv, Ray Scheid, Li Lu & Jiamu Du. Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nature communications 9:2425, 2018.

13.Xiangsong Chen, Li Lu, Shuiming Qian, Mark Scalf, Lyold M Smith, Xuehua Zhong. Canonical and Non-canonical Actions of Arabidopsis Histone Deacetylases in Ribosomal RNA Processing. Plant Cell, 30:134–152, 2018.

14.Huanhuan Niu#, Xiaofeng Liu#, Can Tong, Hu Wang, Sen Li, Li Lu, Yupeng Pan, Xiaolan Zhang, Yiqun Weng, Zheng Li. The WUSCHEL-related homeobox1 gene of cucumber regulates reproductive organ development; Journal of Experimental Botany, 69 (22): 5373–5387, 2018.

15.Sanders D, Qian S, Fieweger R, Lu L, Dowell JA, Denu JM, Zhong X. Histone lysine-to-methionine mutations reduce histone methylation and cause developmental pleiotropy. Plant Physiology, 173(4):2243-2252, 2017.

16.Yangguang Li, Fangyu Wang, Li Lu, Fen Zhu, Shengjian Huang, Krystle Nomie, Liang Zhang, David T Yang, Wei Huang, Brad S Kahl, Stephen Safe, Michael Wang, Lixin Rui. NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells. Blood cancer journal, 7(12),632, 2017.

17.Xiangsong Chen, Li Lu, Kevin S Mayer, Mark Scalf, Shuiming Qian, Aaron Lomax, Lloyd M Smith, Xuehua Zhong. POWERDRESS interacts with HISTONE DEACETYLASE 9 to promote aging in Arabidopsis. eLife 5, e17214. 2016.

18.Lixin Rui, Amanda C Drennan, Michele Ceribelli, Fen Zhu, George W Wright, Da Wei Huang, Wenming Xiao, Yangguang Li, Kreg M Grindle, Li Lu & Louis M Staudt. Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma. PNAS, 113(46), E7260-E7267, 2016.

19.Y Li, MN Bouchlaka, J Wolff, KM Grindle, L Lu & L Rui. FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma. Oncogene, 35(48), 6223-6234. 2016.

20.M Zheng, KB Turton, F Zhu, Y Li, KM Grindle, DS Annis, Li Lu & L Rui. A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture. Oncogenesis, 4 (1), e184, 2016.

21.Jingfang Zhang, Guangyao Kong, Li Lu & Jing Zhang.  p53-/-synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood, blood-2016-06-719237, 2016.

22.Jia Zhang#, Xiangchun Zhou#, Wenhao Yan#, Zhanyi Zhang, Li Lu & Yongzhong Xing. Combinations of the Ghd7, Ghd8 and Hd1 genes largely define the ecogeographical adaptation and yield potential of cultivated rice. New Phytologist, 208(4), 1056-1066, 2015.

23.Wenhao Yan, Haiyang Liu, Xiangchun Zhou, Qiuping Li, Jia Zhang, Li Lu & Yongzhong Xing. Natural variation in Ghd7.1 plays an important role in grain yield and adaptation in rice. Cell Research, 23:969-97, 2013.

招生招聘:

欢迎对本实验室研究方向感兴趣的本科、硕士、博士加盟！

诚聘博士后、科研助理，欢迎联系询问。